• Home  / 
  • Featured
  •  /  Connection Between Antacids And Dementia

Connection Between Antacids And Dementia

Dementia Brains

There have been concerns with the effect of long-term use of antacids for several years. These concerns have generally been in association with a possible link with kidney disease. Now researchers have raised a new concern, with dementia.

Antacids are medications designed to control acid reflux and the resulting heartburn. They are types of Proton Pump Inhibitors (PPIs), and they function by chemically switching off the production of acid in the stomach. The use of the medications is growing.

A new study from the German Center for Neurodegenerative Diseases indicates a link between PPIs and dementia. This is based on a medical review of 74,000 people aged over 75 years and correlating their mental health with medication use. The data was collected over a seven year period.

Of the 74,000 people, some 2,950 regularly used PPIs. This sub-population was found to have a 44 percent higher risk of dementia compared with others in the survey.

Following the assessment the researchers conclude:

“To evaluate cause-and-effect relationships between long-term PPI use and possible effects on cognition in the elderly, randomized, prospective clinical trials are needed. Clinicians should follow guidelines for PPI prescription, to avoid overprescribing PPIs and inappropriate use.”

However, commenting on the findings, Dr. Arun Swaminath, of Lenox Hill Hospital in New York City (who was not involved with the study), told Laboratory Roots that further data is required before a conclusive link should be drawn.

The research is published in the journal Neurology, in a paper headed “Association of Proton Pump Inhibitors With Risk of Dementia:  A Pharmacoepidemiological Claims Data Analysis.”

About the author

Tim Sandle

Dr. Tim Sandle is a chartered biologist and holds a first class honours degree in Applied Biology; a Masters degree in education; and has a doctorate from Keele University.